GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs708547 | 1 | rs708547 | chr4:57821309 | C4orf14 | chr4:57829517-57843826:- | -0.22 | -4.09 | 5.11E-5 | Response to bleomycin (chromatid breaks) |
| THCA | cis | rs7474896 | 1 | rs7086833 | chr10:38277025 | LOC399744 | chr10:38717074-38741080:+ | -0.26 | -3.57 | 0.000393 | Obesity (extreme) |
| THCA | cis | rs6479891 | 1 | rs7087279 | chr10:65291936 | LOC84989 | chr10:65224989-65226320:+ | -0.27 | -4.38 | 1.48E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs7087279 | chr10:65291936 | NRBF2 | chr10:64893007-64914785:+ | -0.27 | -4.46 | 1.02E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs11190604 | 1 | rs7088512 | chr10:102303498 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.2 | 1.13E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs7088827 | chr10:102303865 | SEC31B | chr10:102246403-102289636:- | -0.28 | -9.09 | 2.61E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs7090431 | chr10:102261753 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.74 | 4.1E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs7069346 | 1 | rs7091404 | chr10:124745458 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.12 | 4.51E-5 | Migraine without aura |
| THCA | cis | rs709400 | 1 | rs709400 | chr14:104149475 | KLC1 | chr14:104029299-104167887:+ | -0.22 | -4.37 | 1.52E-5 | Body mass index |
| THCA | cis | rs10741243 | 1 | rs7094311 | chr10:132948685 | TCERG1L | chr10:132890656-133109984:- | 0.4 | 6.04 | 3.08E-9 | Type 2 diabetes |
| THCA | cis | rs7084921 | 1 | rs7094406 | chr10:101815573 | CWF19L1 | chr10:101992055-102027437:- | 0.44 | 7.99 | 1.02E-14 | Bone mineral density |
| THCA | cis | rs7069346 | 1 | rs7095889 | chr10:124744265 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.03 | 6.38E-5 | Migraine without aura |
| THCA | cis | rs8078723 | 1 | rs709592 | chr17:38175553 | GSDMA | chr17:38119226-38134019:+ | -0.32 | -7.25 | 1.67E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs709592 | chr17:38175553 | ORMDL3 | chr17:38077296-38083854:- | 0.14 | 3.37 | 0.000809 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs7095944 | 1 | rs7095944 | chr10:126302936 | METTL10 | chr10:126447406-126480439:- | -0.36 | -8.01 | 8.78E-15 | Asthma |